maximum tolerated dose การใช้

• Maximum tolerated dose studies are also done in clinical trials.
• In the Phase 1b trials shows the safety and pharmacokinetics that help decide what the maximum tolerated dose is.
• Also, how would you want to compare them-the number of pills, the maximum tolerated dose, or some other measure?
• In the first human study of BIBW 2992, the maximum tolerated dose in a two-week-on, two-week off schedule was 70 mg once-daily.
• This is generally defined by the range between the minimum effective dose ( MED ) and the maximum tolerated dose ( MTD ).
• Following inconclusive VEGF-C, circulating endothelial cells, and CD146 and CD34 / 133 counts, and a maximum tolerated dose has still not been established.
• Moreover, the first step in testing ordinary chemotherapy is to check for the maximum tolerated dose _ the amount that stops just short of killing the patient.
• In a phase I study of 25 patients with advanced solid tumours, BIBF 1120 showed a favourable safety and pharmacokinetic profile with a maximum tolerated dose of 250mg.
• In another phase I dose-escalation study, in 22 patients with advanced gynaecological malignancies, the maximum tolerated dose of BIBF 1120 twice-daily combined with paclitaxel and carboplatin was 200mg.
• A maximum tolerated dose of aldoxorubicin has been established at 3.5 times the MTD of doxorubicin, and studies have indicated increased response rates for patients with soft tissue sarcomas.
• The maximum tolerated dose differed between Asian and Caucasian populations ( 80 mg / m2 and 25 mg / m2 respectively ), perhaps due to differences in CYP2A6 genotype.
• The dosage used in the study was eight times greater than the so-called maximum tolerated dose, the amount above which tissue damage occurs even from innocent substances because of the high concentration.
• This is continued until pre-calculated pharmacokinetic safety levels are reached, or intolerable side effects start showing up ( at which point the drug is said to have reached the maximum tolerated dose ( MTD ) ).
• The "'maximum tolerated dose "'( MTD ) refers to the highest dose of a radiological or test subjects ( and, among other things, the cost of testing ), to detect an effect that might occur only rarely.
• They concluded that, at doses up to internationally accepted standards for a maximum tolerated dose, PBO is not considered to be carcinogenic in the mouse or rat, thus leading to the conclusion that PBO is not carcinogenic to humans.
• The authors note that nonetheless, the starting dose will not exceed 33 % of the maximum tolerated dose ( MTD ) identified in the single dose groups ( or 33 % of the maximum administered dose if the MTD is not reached ).
• It is worth noticing however that, when comparing lenalidomide and pomalidomide, clinical relevance of higher in vitro potency is unclear since maximum tolerated dose of pomalidomide is 2 mg daily compared to 25 mg for lenalidomide, leading to 10-100 times lower plasma drug concentration of pomalidomide.